PDF/X-4 CMYK+RGB workflow for digital printing with Adobe CS4-CC
Adobe InDesign and Adobe Illustrator CS4 and newer: direct export of PDF/X-4 CMYK+RGB (CMYK and spot colors as well as ICC-based objects (e.g. RGB images) are allowed). Supports live transparency.
The profile for digital printing is only available for Acrobat XI and DC, since in Acrobat 9 + X important checks are missing or not working properly.